Compile Data Set for Download or QSAR

Found 1413 hits of ic50 data for polymerid = 49000889,49000994,49000996,4936   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50/IC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035145 (1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...) Show SMILES C(COC1CCCCC1)CN1CCC2(CC1)OCc1ccccc21 Show InChI InChI=1S/C21H31NO2/c1-2-8-19(9-3-1)23-16-6-13-22-14-11-21(12-15-22)20-10-5-4-7-18(20)17-24-21/h4-5,7,10,19H,1-3,6,8-9,11-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035141 (1'-(cyclohexylbutyl)-3H-spiro[2-benzofuran-1,4'-pi...) Show SMILES C(CCN1CCC2(CC1)OCc1ccccc21)CC1CCCCC1 Show InChI InChI=1S/C22H33NO/c1-2-8-19(9-3-1)10-6-7-15-23-16-13-22(14-17-23)21-12-5-4-11-20(21)18-24-22/h4-5,11-12,19H,1-3,6-10,13-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.0700	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50054124 (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) Show SMILES COc1cccc2C(CCCN3CCCC(C)(C)C3)CCCc12 Show InChI InChI=1S/C21H33NO/c1-21(2)13-7-15-22(16-21)14-6-9-17-8-4-11-19-18(17)10-5-12-20(19)23-3/h5,10,12,17H,4,6-9,11,13-16H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0890	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.				J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50054124 (1-[3-(5-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) Show SMILES COc1cccc2C(CCCN3CCCC(C)(C)C3)CCCc12 Show InChI InChI=1S/C21H33NO/c1-21(2)13-7-15-22(16-21)14-6-9-17-8-4-11-19-18(17)10-5-12-20(19)23-3/h5,10,12,17H,4,6-9,11,13-16H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.0890	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.				J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035105 (1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...) Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccccc32)c2ccccc12 Show InChI InChI=1S/C30H31FN2O/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.120	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035133 (1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...) Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)SCc2ccccc32)c2ccccc12 Show InChI InChI=1S/C30H31FN2S/c31-25-12-14-26(15-13-25)33-21-23(27-9-2-4-11-29(27)33)7-5-6-18-32-19-16-30(17-20-32)28-10-3-1-8-24(28)22-34-30/h1-4,8-15,21H,5-7,16-20,22H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	PubMed	n/a	n/a	0.140	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035122 (1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...) Show SMILES C(CCN1CCC2(CC1)OCc1ccccc21)CCc1ccccc1 Show InChI InChI=1S/C23H29NO/c1-3-9-20(10-4-1)11-5-2-8-16-24-17-14-23(15-18-24)22-13-7-6-12-21(22)19-25-23/h1,3-4,6-7,9-10,12-13H,2,5,8,11,14-19H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035144 (1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...) Show SMILES C(CCCc1ccccc1)CCN1CCC2(CC1)OCc1ccccc21 Show InChI InChI=1S/C24H31NO/c1(4-10-21-11-5-3-6-12-21)2-9-17-25-18-15-24(16-19-25)23-14-8-7-13-22(23)20-26-24/h3,5-8,11-14H,1-2,4,9-10,15-20H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.200	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035129 (1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...) Show SMILES C(CCc1ccccc1)CN1CCC2(CC1)OCc1ccccc21 Show InChI InChI=1S/C22H27NO/c1-2-8-19(9-3-1)10-6-7-15-23-16-13-22(14-17-23)21-12-5-4-11-20(21)18-24-22/h1-5,8-9,11-12H,6-7,10,13-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.25	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50421905 (CHEMBL553265) Show SMILES C1CCC(CC1)N1CC[C@@H]2[C@@H](CCc3ccccc23)C1 |r| Show InChI InChI=1S/C19H27N/c1-2-7-17(8-3-1)20-13-12-19-16(14-20)11-10-15-6-4-5-9-18(15)19/h4-6,9,16-17,19H,1-3,7-8,10-14H2/t16-,19+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.251	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellum				J Med Chem 35: 2025-33 (1992) BindingDB Entry DOI: 10.7270/Q2MP54K8
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035097 (1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...) Show SMILES C(N1CCC2(CCCc3ccccc23)CC1)c1ccccc1 Show InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine				J Med Chem 38: 1998-2008 (1995) BindingDB Entry DOI: 10.7270/Q2SJ1M8P
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035097 (1''-benzyl-3,4-dihydro-2H-spiro[naphthalene-1,4''-...) Show SMILES C(N1CCC2(CCCc3ccccc23)CC1)c1ccccc1 Show InChI InChI=1S/C21H25N/c1-2-7-18(8-3-1)17-22-15-13-21(14-16-22)12-6-10-19-9-4-5-11-20(19)21/h1-5,7-9,11H,6,10,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035134 (1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...) Show SMILES C(CSC1CCCCC1)CN1CCC2(CC1)OCc1ccccc21 Show InChI InChI=1S/C21H31NOS/c1-2-8-19(9-3-1)24-16-6-13-22-14-11-21(12-15-22)20-10-5-4-7-18(20)17-23-21/h4-5,7,10,19H,1-3,6,8-9,11-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	0.260	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035129 (1'-(2-phenylbutyl)-3H-spiro[2-benzofuran-1,4'-pipe...) Show SMILES C(CCc1ccccc1)CN1CCC2(CC1)OCc1ccccc21 Show InChI InChI=1S/C22H27NO/c1-2-8-19(9-3-1)10-6-7-15-23-16-13-22(14-17-23)21-12-5-4-11-20(21)18-24-22/h1-5,8-9,11-12H,6-7,10,13-18H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50382166 (CHEMBL2023825) Show SMILES C1CCC(CC1)N1CCN(CC1)c1ccc(cc1)C(c1ccccc1)C12CC3CC(CC(C3)C1)C2 |TLB:18:25:28.27.32:30,THB:26:27:30:34.25.33,26:25:28.27.32:30,33:25:28:32.31.30,33:31:28:34.26.25,18:25:28:32.31.30| Show InChI InChI=1S/C33H44N2/c1-3-7-28(8-4-1)32(33-22-25-19-26(23-33)21-27(20-25)24-33)29-11-13-31(14-12-29)35-17-15-34(16-18-35)30-9-5-2-6-10-30/h1,3-4,7-8,11-14,25-27,30,32H,2,5-6,9-10,15-24H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.270	n/a	n/a	n/a	n/a	n/a	n/a
National and Kapodistrian University of Athens Curated by ChEMBL					Assay Description Displacement of [3H](+)pentazocine from sigma-1 receptor expressed in human Jurkat cell membranes after 2 hrs by liquid scintillation spectroscopy				Bioorg Med Chem 20: 3323-31 (2012) Article DOI: 10.1016/j.bmc.2012.03.038 BindingDB Entry DOI: 10.7270/Q20V8DT0
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50040283 (3-Chloro-6-dimethylamino-6-methyl-8-phenyl-5,6,7,8...) Show SMILES CN(C)[C@@H]1C[C@@H](c2ccccc2)c2cc(O)c(Cl)cc2C1 Show InChI InChI=1S/C18H20ClNO/c1-20(2)14-8-13-9-17(19)18(21)11-16(13)15(10-14)12-6-4-3-5-7-12/h3-7,9,11,14-15,21H,8,10H2,1-2H3/t14-,15-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.290	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligand				J Med Chem 36: 2542-51 (1993) BindingDB Entry DOI: 10.7270/Q2C53MGM
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035142 (1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[6-fluorospi...) Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2ccc(F)cc32)c2ccccc12 Show InChI InChI=1S/C30H30F2N2O/c31-24-10-12-26(13-11-24)34-20-22(27-6-1-2-7-29(27)34)5-3-4-16-33-17-14-30(15-18-33)28-19-25(32)9-8-23(28)21-35-30/h1-2,6-13,19-20H,3-5,14-18,21H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.310	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50421907 (CHEMBL540274) Show SMILES C(Cc1ccccc1)N1CC[C@@H]2[C@@H](CCc3ccccc23)C1 |r,@:8| Show InChI InChI=1S/C21H25N/c1-2-6-17(7-3-1)12-14-22-15-13-21-19(16-22)11-10-18-8-4-5-9-20(18)21/h1-9,19,21H,10-16H2/t19-,21+/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.324	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro for the binding affinity against sigma receptor by using [3H]DTG as radioligand in guinea pig cerebellum				J Med Chem 35: 2025-33 (1992) BindingDB Entry DOI: 10.7270/Q2MP54K8
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035135 (1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...) Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)COCc2ccccc32)c2ccccc12 Show InChI InChI=1S/C31H33FN2O/c32-26-12-14-27(15-13-26)34-21-24(28-9-2-4-11-30(28)34)7-5-6-18-33-19-16-31(17-20-33)23-35-22-25-8-1-3-10-29(25)31/h1-4,8-15,21H,5-7,16-20,22-23H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.340	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035145 (1'-(3-cyclohexyloxypropyl)-3H-spiro[2-benzofuran-1...) Show SMILES C(COC1CCCCC1)CN1CCC2(CC1)OCc1ccccc21 Show InChI InChI=1S/C21H31NO2/c1-2-8-19(9-3-1)23-16-6-13-22-14-11-21(12-15-22)20-10-5-4-7-18(20)17-24-21/h4-5,7,10,19H,1-3,6,8-9,11-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.400	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50036730 (3-[4-(4-Chloro-phenyl)-3,6-dihydro-2H-pyridin-1-yl...) Show SMILES Clc1ccc(cc1)C1=CCN(CCC(=O)c2ccccc2)CC1 |t:8| Show InChI InChI=1S/C20H20ClNO/c21-19-8-6-16(7-9-19)17-10-13-22(14-11-17)15-12-20(23)18-4-2-1-3-5-18/h1-10H,11-15H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
New York University Curated by ChEMBL					Assay Description Binding affinity against sigma receptor in bovine cerebellum using 2.0 nM [3H]-haloperidol in the presence of 25 nM unlabeled spiperone				J Med Chem 36: 3923-8 (1994) BindingDB Entry DOI: 10.7270/Q2H13122
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50054728 (1,4-Bis-(3-phenyl-propyl)-piperazine | CHEMBL34640...) Show SMILES C(CN1CCN(CCCc2ccccc2)CC1)Cc1ccccc1 Show InChI InChI=1S/C22H30N2/c1-3-9-21(10-4-1)13-7-15-23-17-19-24(20-18-23)16-8-14-22-11-5-2-6-12-22/h1-6,9-12H,7-8,13-20H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article PubMed	n/a	n/a	0.5	n/a	n/a	n/a	n/a	n/a	n/a
National Institute of Diabetes and Digestive and Kidney Diseases Curated by ChEMBL					Assay Description Binding affinity against sigma receptor using radioligand ([3H](+)-pentazocine) binding assay				J Med Chem 39: 4704-16 (1997) Article DOI: 10.1021/jm960305h BindingDB Entry DOI: 10.7270/Q2QZ2BN6
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50040287 ((1R,3S)Dimethyl-(2-methyl-4-phenyl-1,2,3,4-tetrahy...) Show SMILES CN(C)[C@]1(C)C[C@@H](c2ccccc2)c2ccccc2C1 Show InChI InChI=1S/C19H23N/c1-19(20(2)3)13-16-11-7-8-12-17(16)18(14-19)15-9-5-4-6-10-15/h4-12,18H,13-14H2,1-3H3/t18-,19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Binding affinity against sigma receptor from guinea pig brain (minus cerebellum) homogenates, using the novel [3H]-(+/-)-4 as radioligand				J Med Chem 36: 2542-51 (1993) BindingDB Entry DOI: 10.7270/Q2C53MGM
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50040287 ((1R,3S)Dimethyl-(2-methyl-4-phenyl-1,2,3,4-tetrahy...) Show SMILES CN(C)[C@]1(C)C[C@@H](c2ccccc2)c2ccccc2C1 Show InChI InChI=1S/C19H23N/c1-19(20(2)3)13-16-11-7-8-12-17(16)18(14-19)15-9-5-4-6-10-15/h4-12,18H,13-14H2,1-3H3/t18-,19-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.510	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description Binding affinity against dopamine receptor D1 from rat striatal homogenates, using [3H]SCH-23390 as radioligand.				J Med Chem 36: 2542-51 (1993) BindingDB Entry DOI: 10.7270/Q2C53MGM
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM86029 (trans-H2-PAT(+)) Show SMILES CN(C)[C@@H]1C[C@@H](c2ccccc2)c2ccccc2C1 |r| Show InChI InChI=1S/C18H21N/c1-19(2)16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,12-13H2,1-2H3/t16-,18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.520	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description The compound was tested for affinity towards sigma-3 receptor				J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM86029 (trans-H2-PAT(+)) Show SMILES CN(C)[C@@H]1C[C@@H](c2ccccc2)c2ccccc2C1 |r| Show InChI InChI=1S/C18H21N/c1-19(2)16-12-15-10-6-7-11-17(15)18(13-16)14-8-4-3-5-9-14/h3-11,16,18H,12-13H2,1-2H3/t16-,18-/m0/s1	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.525	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description The compound was tested for affinity towards sigma-3 receptor				J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035144 (1'-(2-phenylhexyl)-3H-spiro[2-benzofuran-1,4'-pipe...) Show SMILES C(CCCc1ccccc1)CCN1CCC2(CC1)OCc1ccccc21 Show InChI InChI=1S/C24H31NO/c1(4-10-21-11-5-3-6-12-21)2-9-17-25-18-15-24(16-19-25)23-14-8-7-13-22(23)20-26-24/h3,5-8,11-14H,1-2,4,9-10,15-20H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.530	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035128 (1'-(2-phenylpropyl)-3H-spiro[2-benzofuran-1,4'-pip...) Show SMILES C(CN1CCC2(CC1)OCc1ccccc21)Cc1ccccc1 Show InChI InChI=1S/C21H25NO/c1-2-7-18(8-3-1)9-6-14-22-15-12-21(13-16-22)20-11-5-4-10-19(20)17-23-21/h1-5,7-8,10-11H,6,9,12-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.560	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035124 (1-[1-(4-fluorophenyl)-1H-3-indolyl]-4-[7-fluorospi...) Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCc2cccc(F)c32)c2ccccc12 Show InChI InChI=1S/C30H30F2N2O/c31-24-11-13-25(14-12-24)34-20-22(26-8-1-2-10-28(26)34)6-3-4-17-33-18-15-30(16-19-33)29-23(21-35-30)7-5-9-27(29)32/h1-2,5,7-14,20H,3-4,6,15-19,21H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.580	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50289537 (1-(3-Phenyl-propyl)-3-((Z)-styryl)-piperidine | CH...) Show SMILES C(CN1CCCC(C1)\C=C/c1ccccc1)Cc1ccccc1 Show InChI InChI=1S/C22H27N/c1-3-9-20(10-4-1)13-7-17-23-18-8-14-22(19-23)16-15-21-11-5-2-6-12-21/h1-6,9-12,15-16,22H,7-8,13-14,17-19H2/b16-15-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	0.600	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.				Bioorg Med Chem Lett 7: 1525-1530 (1997) Article DOI: 10.1016/S0960-894X(97)00253-9 BindingDB Entry DOI: 10.7270/Q2N58MCN
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50067018 (1-[5-(6-Methoxy-1,2,3,4-tetrahydro-naphthalen-1-yl...) Show SMILES COc1ccc2C(CCCCCN3CCCC(C)(C)C3)CCCc2c1 Show InChI InChI=1S/C23H37NO/c1-23(2)14-8-16-24(18-23)15-6-4-5-9-19-10-7-11-20-17-21(25-3)12-13-22(19)20/h12-13,17,19H,4-11,14-16,18H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.620	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.				J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards sigma receptor binding site 1 using [3H](+)-pentazocine				J Med Chem 38: 1998-2008 (1995) BindingDB Entry DOI: 10.7270/Q2SJ1M8P
					More data for this Ligand-Target Pair				3D Structure (crystal)
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM21398 (4-[4-(4-Chloro-phenyl)-4-hydroxy-piperidin-1-yl]-1...) Show SMILES OC1(CCN(CCCC(=O)c2ccc(F)cc2)CC1)c1ccc(Cl)cc1 Show InChI InChI=1S/C21H23ClFNO2/c22-18-7-5-17(6-8-18)21(26)11-14-24(15-12-21)13-1-2-20(25)16-3-9-19(23)10-4-16/h3-10,26H,1-2,11-15H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	Purchase CHEMBL DrugBank MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PDB PubMed	n/a	n/a	0.650	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair				3D Structure (crystal)
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50054121 (3,3-Dimethyl-1-[4-(1,2,3,4-tetrahydro-naphthalen-1...) Show SMILES CC1(C)CCCN(CCCCC2CCCc3ccccc23)C1 Show InChI InChI=1S/C21H33N/c1-21(2)14-8-16-22(17-21)15-6-5-10-19-12-7-11-18-9-3-4-13-20(18)19/h3-4,9,13,19H,5-8,10-12,14-17H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.690	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.				J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50040282 (CHEMBL317029 | CHEMBL545249 | cis-3-Chloro-6-dimet...) Show SMILES CN(C)C1CC(c2ccccc2)c2cc(O)c(Cl)cc2C1 Show InChI InChI=1S/C18H20ClNO/c1-20(2)14-8-13-9-17(19)18(21)11-16(13)15(10-14)12-6-4-3-5-7-12/h3-7,9,11,14-15,21H,8,10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.708	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description The compound was tested for affinity towards sigma-3 receptor				J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50040282 (CHEMBL317029 | CHEMBL545249 | cis-3-Chloro-6-dimet...) Show SMILES CN(C)C1CC(c2ccccc2)c2cc(O)c(Cl)cc2C1 Show InChI InChI=1S/C18H20ClNO/c1-20(2)14-8-13-9-17(19)18(21)11-16(13)15(10-14)12-6-4-3-5-7-12/h3-7,9,11,14-15,21H,8,10H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.710	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description The compound was tested for affinity towards sigma-3 receptor				J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50421946 (CHEMBL1788383) Show SMILES C(N1CCC2(CCc3ccccc23)CC1)c1ccccc1 Show InChI InChI=1S/C20H23N/c1-2-6-17(7-3-1)16-21-14-12-20(13-15-21)11-10-18-8-4-5-9-19(18)20/h1-9H,10-16H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.724	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.				J Med Chem 35: 2033-9 (1992) BindingDB Entry DOI: 10.7270/Q2GX4CVJ
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50289553 (1-Phenethyl-3-((Z)-styryl)-piperidine | CHEMBL3697...) Show SMILES C(Cc1ccccc1)N1CCCC(C1)\C=C/c1ccccc1 Show InChI InChI=1S/C21H25N/c1-3-8-19(9-4-1)13-14-21-12-7-16-22(18-21)17-15-20-10-5-2-6-11-20/h1-6,8-11,13-14,21H,7,12,15-18H2/b14-13-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	0.800	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.				Bioorg Med Chem Lett 7: 1525-1530 (1997) Article DOI: 10.1016/S0960-894X(97)00253-9 BindingDB Entry DOI: 10.7270/Q2N58MCN
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035122 (1'-(2-phenylpentyl)-3H-spiro[2-benzofuran-1,4'-pip...) Show SMILES C(CCN1CCC2(CC1)OCc1ccccc21)CCc1ccccc1 Show InChI InChI=1S/C23H29NO/c1-3-9-20(10-4-1)11-5-2-8-16-24-17-14-23(15-18-24)22-13-7-6-12-21(22)19-25-23/h1,3-4,6-7,9-10,12-13H,2,5,8,11,14-19H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	0.820	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50172914 ((S)-2-(2-Piperidin-1-yl-ethyl)-3-thioxo-2,3,10,10a...) Show SMILES Oc1c2Cc3ccccc3Cn2c(=S)n1CCN1CCCCC1 Show InChI InChI=1S/C18H23N3OS/c22-17-16-12-14-6-2-3-7-15(14)13-21(16)18(23)20(17)11-10-19-8-4-1-5-9-19/h2-3,6-7,22H,1,4-5,8-13H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
Université de Lille II Curated by ChEMBL					Assay Description Inhibitory concentration against opioid receptor sigma 1 of guinea pig cerebral cortex using [3H]-(+)-pentazocine upon incubation for 150 minutes at ...				Bioorg Med Chem Lett 15: 4833-7 (2005) Article DOI: 10.1016/j.bmcl.2005.07.040 BindingDB Entry DOI: 10.7270/Q2PN9553
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035120 (1'-{4-[1-(4-fluorophenyl)-1H-3-indolyl]butyl}spiro...) Show SMILES Fc1ccc(cc1)-n1cc(CCCCN2CCC3(CC2)OCCc2ccccc32)c2ccccc12 Show InChI InChI=1S/C31H33FN2O/c32-26-12-14-27(15-13-26)34-23-25(28-9-2-4-11-30(28)34)8-5-6-19-33-20-17-31(18-21-33)29-10-3-1-7-24(29)16-22-35-31/h1-4,7,9-15,23H,5-6,8,16-22H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	0.900	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Binding affinity towards Sigma receptor site 2 in rat brain using [3H]DTG as radioligand				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50035134 (1'-(3-(cyclohexylthio)propyl)-3H-spiro[2-benzofura...) Show SMILES C(CSC1CCCCC1)CN1CCC2(CC1)OCc1ccccc21 Show InChI InChI=1S/C21H31NOS/c1-2-8-19(9-3-1)24-16-6-13-22-14-11-21(12-15-22)20-10-5-4-7-18(20)17-23-21/h4-5,7,10,19H,1-3,6,8-9,11-17H2	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents	PubMed	n/a	n/a	0.960	n/a	n/a	n/a	n/a	n/a	n/a
H. Lundbeck A/S Curated by ChEMBL					Assay Description Compound was evaluated for the binding affinity towards Sigma receptor type 1 using radioligand ([3H]-(+)- Pentazocine) binding assay.				J Med Chem 38: 2009-17 (1995) BindingDB Entry DOI: 10.7270/Q2NS0VKD
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50067019 (1-[3-(3H-Inden-1-yl)-propyl]-3,3-dimethyl-piperidi...) Show SMILES CC1(C)CCCN(CCCC2=CCc3ccccc23)C1 |t:10| Show InChI InChI=1S/C19H27N/c1-19(2)12-6-14-20(15-19)13-5-8-17-11-10-16-7-3-4-9-18(16)17/h3-4,7,9,11H,5-6,8,10,12-15H2,1-2H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	0.990	n/a	n/a	n/a	n/a	n/a	n/a
Università di Bari Curated by ChEMBL					Assay Description Evaluated for the binding affinity towards sigma 1 receptor by displacing the radioligand [3H]-SKF- 10047 in whole rat brain membrane.				J Med Chem 41: 3940-7 (1998) Article DOI: 10.1021/jm970692a BindingDB Entry DOI: 10.7270/Q2NK3D5Q
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50074867 ((2-{4-Methoxy-3-[2-(4-methoxy-phenyl)-ethoxy]-phen...) Show SMILES CCCN(CCC)CCc1ccc(OC)c(OCCc2ccc(OC)cc2)c1 Show InChI InChI=1S/C24H35NO3/c1-5-15-25(16-6-2)17-13-21-9-12-23(27-4)24(19-21)28-18-14-20-7-10-22(26-3)11-8-20/h7-12,19H,5-6,13-18H2,1-4H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membrane				J Med Chem 42: 1076-87 (1999) Article DOI: 10.1021/jm980212v BindingDB Entry DOI: 10.7270/Q29C6Z4V
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50282973 (4-Fluoro-N-{1-(4-fluoro-naphthalen-1-yl)-4-[4-(5-f...) Show SMILES Fc1ccc(cc1)S(=O)(=O)NC(CCCN1CCN(CC1)c1ncc(F)cn1)c1ccc(F)c2ccccc12 Show InChI InChI=1S/C28H28F3N5O2S/c29-20-7-9-22(10-8-20)39(37,38)34-27(25-11-12-26(31)24-5-2-1-4-23(24)25)6-3-13-35-14-16-36(17-15-35)28-32-18-21(30)19-33-28/h1-2,4-5,7-12,18-19,27,34H,3,6,13-17H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Patents Similars	Article	n/a	n/a	>1	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description In vitro binding affinity of the compound towards sigma receptor by the displacement of [3H]-PPP from guinea pig brain				Bioorg Med Chem Lett 4: 1941-1946 (1994) Article DOI: 10.1016/S0960-894X(01)80539-4 BindingDB Entry DOI: 10.7270/Q28C9W6R
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50289552 (1-(3-Methyl-but-2-enyl)-3-((Z)-styryl)-piperidine ...) Show SMILES [#6]\[#6](-[#6])=[#6]/[#6]-[#7]-1-[#6]-[#6]-[#6]-[#6](-[#6]-1)\[#6]=[#6]/c1ccccc1 Show InChI InChI=1S/C18H25N/c1-16(2)12-14-19-13-6-9-18(15-19)11-10-17-7-4-3-5-8-17/h3-5,7-8,10-12,18H,6,9,13-15H2,1-2H3/b11-10-	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	Article	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
TBA Curated by ChEMBL					Assay Description Binding affinity at sigma receptor by [3H]-(+)-SKF-10,047 displacement.				Bioorg Med Chem Lett 7: 1525-1530 (1997) Article DOI: 10.1016/S0960-894X(97)00253-9 BindingDB Entry DOI: 10.7270/Q2N58MCN
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM50421940 (CHEMBL62770) Show SMILES [#6]\[#6](-[#6])=[#6]\[#6]-[#7]-1-[#6]-[#6]C2([#6]-[#6]-[#6]-c3ccccc23)[#6]-[#6]-1 Show InChI InChI=1S/C19H27N/c1-16(2)9-13-20-14-11-19(12-15-20)10-5-7-17-6-3-4-8-18(17)19/h3-4,6,8-9H,5,7,10-15H2,1-2H3	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Merck Sharp and Dohme Research Laboratories Curated by ChEMBL					Assay Description In vitro binding affinity against sigma receptor by using [3H]-DTG ([3H]-6) as radioligand in guinea pig cerebellum.				J Med Chem 35: 2033-9 (1992) BindingDB Entry DOI: 10.7270/Q2GX4CVJ
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Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM22165 (1-{2-[bis(4-fluorophenyl)methoxy]ethyl}-4-(3-pheny...) Show SMILES Fc1ccc(cc1)C(OCCN1CCN(CCCc2ccccc2)CC1)c1ccc(F)cc1 Show InChI InChI=1S/C28H32F2N2O/c29-26-12-8-24(9-13-26)28(25-10-14-27(30)15-11-25)33-22-21-32-19-17-31(18-20-32)16-4-7-23-5-2-1-3-6-23/h1-3,5-6,8-15,28H,4,7,16-22H2	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE PC cid PC sid UniChem Patents Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description The compound was tested for affinity towards sigma-3 receptor				J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57
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Sigma non-opioid intracellular receptor 1 (Homo sapiens (Human))	BDBM21395 (3-(2-(4-(4-Fluorobenzoyl)piperidinol)ethyl)-2,4(1H...) Show SMILES Fc1ccc(cc1)C(=O)C1CCN(CCn2c(=O)[nH]c3ccccc3c2=O)CC1 Show InChI InChI=1S/C22H22FN3O3/c23-17-7-5-15(6-8-17)20(27)16-9-11-25(12-10-16)13-14-26-21(28)18-3-1-2-4-19(18)24-22(26)29/h1-8,16H,9-14H2,(H,24,29)	PDB UniProtKB/SwissProt antibodypedia GoogleScholar AffyNet	Purchase CHEMBL MCE KEGG PC cid PC sid PDB UniChem Patents Similars	PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
University of North Carolina Curated by ChEMBL					Assay Description The compound was tested for affinity towards sigma-3 receptor				J Med Chem 37: 4109-17 (1995) BindingDB Entry DOI: 10.7270/Q2QF8V57
					More data for this Ligand-Target Pair
Sigma non-opioid intracellular receptor 1 (RAT)	BDBM50074846 (CHEMBL545597 | [3-(4-Methoxy-3-phenethyloxy-phenyl...) Show SMILES CCCN(CCC)CCCc1ccc(OC)c(OCCc2ccccc2)c1 Show InChI InChI=1S/C24H35NO2/c1-4-16-25(17-5-2)18-9-12-22-13-14-23(26-3)24(20-22)27-19-15-21-10-7-6-8-11-21/h6-8,10-11,13-14,20H,4-5,9,12,15-19H2,1-3H3	PDB UniProtKB/SwissProt GoogleScholar AffyNet	CHEMBL PC cid PC sid UniChem	Article PubMed	n/a	n/a	1	n/a	n/a	n/a	n/a	n/a	n/a
Taisho Pharmaceutical Company, Ltd. Curated by ChEMBL					Assay Description Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membrane				J Med Chem 42: 1076-87 (1999) Article DOI: 10.1021/jm980212v BindingDB Entry DOI: 10.7270/Q29C6Z4V
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